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Cognitive & Neuroprotective

RG3 + Methylcobalamin + NAD+

Clinic-compounded cognitive stack pairing an 'RG3' component with B12 and NAD+; components vary and the combo is unstudied.

InvestigationalEvidence level 1 of 5: Preclinical / anecdotalAlso: RG3 stack, Cognitive IV/IM stack, Ginsenoside Rg3 + B12 + NAD+

Overview

This is a clinic-style combination rather than a single compound. It pairs methylcobalamin, an active form of vitamin B12 that supports methylation and nerve health, with NAD+, a coenzyme central to mitochondrial energy production and DNA repair that declines with age. The third component, 'RG3', is inconsistently defined: some suppliers mean ginsenoside Rg3, a ginseng saponin with anti-inflammatory and neuroprotective effects in animal studies, while others mean a Selank-related peptide. The rationale is layered support for energy, mood and cognition. Only B12 has strong evidence, and only in people who are deficient. Confirming exactly what 'RG3' is in a given product is essential before use, and NAD+ infusions must be given slowly.

Classification
Combination: 'RG3' (ginsenoside Rg3 or a Selank-related peptide, depending on source) + methylcobalamin + NAD+
Route
Intravenous (NAD+), intramuscular (methylcobalamin), intranasal or oral (RG3 component)
Half-life
Component-dependent (NAD+ IV: short, minutes to hours; methylcobalamin: days)

Mechanism of action

Primary targetMethylation (B12), mitochondrial NAD+ pool, and neuromodulation (Rg3/peptide)
  1. Methylcobalamin repletionRestores B12-dependent methionine synthase, lowering homocysteine and supporting myelin.
  2. NAD+ supplyRaises NAD+ available for mitochondrial redox reactions and sirtuin/PARP enzymes.
  3. Mitochondrial energy supportImproved oxidative phosphorylation capacity in energy-demanding neurons (theoretical in humans).
  4. Rg3 or peptide neuromodulationGinsenoside Rg3 reduces neuroinflammation in animals; Selank-type peptides modulate GABA and BDNF.
  5. Integrated neural supportCombined effects aim at energy, mood and cognitive clarity.
Downstream effects
  • Corrects B12 deficiency
  • Subjective energy and clarity
  • Unproven cognitive benefit

Researched for

  • Cognitive fatigue
  • Low energy and mood
  • Vitamin B12 deficiency and neuropathy
  • Healthy-aging protocols

Research notes

  • Vitamin B12 treatment improves neurologic and cognitive symptoms only when a true deficiency exists.
  • IV NAD+ raises blood NAD+ levels, but controlled outcome trials for cognition or fatigue are lacking.
  • Ginsenoside Rg3 shows neuroprotective and anti-amyloid effects in rodents; human cognitive data are minimal.
  • No study has evaluated this three-part combination; product identity of 'RG3' varies.

Reported side effects

  • Flushing, chest tightness or nausea with rapid NAD+ infusion
  • Injection-site pain (IM B12)
  • Headache or dizziness
  • Rare acne or rash with high-dose B12

Contraindications & cautions

  • Leber's hereditary optic neuropathy or cobalt/cobalamin allergy (B12)
  • Unclear product identity ('RG3' not verified)
  • Pregnancy and breastfeeding
  • Unstable cardiovascular disease (NAD+ infusion)

Lab monitoring

  • CBC with MCV
  • Vitamin B12, methylmalonic acid, homocysteine
  • Folate, iron panel
  • CMP
  • Blood pressure and heart rate before each infusion

Dosing and pricing for RG3 + Methylcobalamin + NAD+

Dosing references and compound pricing are available to established patients in the secure portal after a medical evaluation.

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